Hi;
I started playing after I became side paralyzed due to a stroke, and I find the ranged attackers are the easiest to play, especially with ranger pets/necromancer minions to pin down or distract the bads if I have to run away from the fight. I have tried the berserker/guardian/revenant types, but they are (for me) too taxing to keep track of cooldown/power usage order/just hitting the power keys in the middle of a fight. They are do-able though, if I take my time with the various fights, don't aggro in too many mobs at once, and just accept a slower completion pace than other players.
I also use a foot board for wasd, and thank god Razer re-released the left handed Naga edition - the thumb board is a god send.